https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Rare genome-wide copy number variation and expression of schizophrenia in 22q11.2 deletion syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33797 Tue 15 Jan 2019 15:29:29 AEDT ]]> Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34283 −15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10−6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10−11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10−5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.]]> Tue 03 Sep 2019 18:30:49 AEST ]]>